Among them, the symmetrical substituted compound 2 and 6 had higher activity than mono-substituted compound 3, 4 and 7. Especially, compounds 2a-2f remarkably exhibited higher inhibition in comparison with artemisinin and artesunate. 青蒿素母核对称取代2和6的活性高于青蒿素母核单取代的3,4和7。化合物2a~2f的活性比青蒿素、青蒿琥酯高。